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sr bi sirna  (Santa Cruz Biotechnology)


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    Structured Review

    Santa Cruz Biotechnology sr bi sirna
    Role of SR-B I and cholesterol efflux in the anti-inflammatory properties of Por-NPs in macrophages . iBMDMs were transfected with SR-BI <t>siRNA</t> (100 nM) to knockdown SR-BI. RT-qPCR measurement of (A) Il1b mRNA and (B) Ccl5 mRNA following incubation with discoidal Por-NPs and stimulation with LPS (10 ng/mL) (n = 3 biological replicates). iBMDMs were pre-incubated with PBS, methyl-β-cyclodextrin (MβCD, 4 % v/v), discoidal or CO-loaded Por-NPs (10 μg/mL) then stimulated with LPS (10 ng/mL) before RT-qPCR quantification of the mRNA levels of (C) Il1b and (D) Ccl5 . The nuclear fractions of (E) unstimulated and (F) LPS-stimulated iBMDMs were isolated and nuclear p65-NFκB protein levels (∼65 kDa) were assessed by Western blotting (n = 5–6 biological replicates). TATA binding protein (TBP, 37 kDa) was used as the nuclear protein loading control. Data expressed as Mean ± SD. ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001, ∗∗∗∗ P < 0.0001 by one-way ANOVA with post-hoc Tukey's multiple comparisons.
    Sr Bi Sirna, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 91/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sr bi sirna/product/Santa Cruz Biotechnology
    Average 91 stars, based on 5 article reviews
    sr bi sirna - by Bioz Stars, 2026-05
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    Images

    1) Product Images from "Theranostic porphyrin nanoparticles identify atherosclerosis via multimodal imaging and elicit atheroprotective effects"

    Article Title: Theranostic porphyrin nanoparticles identify atherosclerosis via multimodal imaging and elicit atheroprotective effects

    Journal: Materials Today Bio

    doi: 10.1016/j.mtbio.2025.102202

    Role of SR-B I and cholesterol efflux in the anti-inflammatory properties of Por-NPs in macrophages . iBMDMs were transfected with SR-BI siRNA (100 nM) to knockdown SR-BI. RT-qPCR measurement of (A) Il1b mRNA and (B) Ccl5 mRNA following incubation with discoidal Por-NPs and stimulation with LPS (10 ng/mL) (n = 3 biological replicates). iBMDMs were pre-incubated with PBS, methyl-β-cyclodextrin (MβCD, 4 % v/v), discoidal or CO-loaded Por-NPs (10 μg/mL) then stimulated with LPS (10 ng/mL) before RT-qPCR quantification of the mRNA levels of (C) Il1b and (D) Ccl5 . The nuclear fractions of (E) unstimulated and (F) LPS-stimulated iBMDMs were isolated and nuclear p65-NFκB protein levels (∼65 kDa) were assessed by Western blotting (n = 5–6 biological replicates). TATA binding protein (TBP, 37 kDa) was used as the nuclear protein loading control. Data expressed as Mean ± SD. ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001, ∗∗∗∗ P < 0.0001 by one-way ANOVA with post-hoc Tukey's multiple comparisons.
    Figure Legend Snippet: Role of SR-B I and cholesterol efflux in the anti-inflammatory properties of Por-NPs in macrophages . iBMDMs were transfected with SR-BI siRNA (100 nM) to knockdown SR-BI. RT-qPCR measurement of (A) Il1b mRNA and (B) Ccl5 mRNA following incubation with discoidal Por-NPs and stimulation with LPS (10 ng/mL) (n = 3 biological replicates). iBMDMs were pre-incubated with PBS, methyl-β-cyclodextrin (MβCD, 4 % v/v), discoidal or CO-loaded Por-NPs (10 μg/mL) then stimulated with LPS (10 ng/mL) before RT-qPCR quantification of the mRNA levels of (C) Il1b and (D) Ccl5 . The nuclear fractions of (E) unstimulated and (F) LPS-stimulated iBMDMs were isolated and nuclear p65-NFκB protein levels (∼65 kDa) were assessed by Western blotting (n = 5–6 biological replicates). TATA binding protein (TBP, 37 kDa) was used as the nuclear protein loading control. Data expressed as Mean ± SD. ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001, ∗∗∗∗ P < 0.0001 by one-way ANOVA with post-hoc Tukey's multiple comparisons.

    Techniques Used: Transfection, Knockdown, Quantitative RT-PCR, Incubation, Isolation, Western Blot, Binding Assay, Control



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    Image Search Results


    Role of SR-B I and cholesterol efflux in the anti-inflammatory properties of Por-NPs in macrophages . iBMDMs were transfected with SR-BI siRNA (100 nM) to knockdown SR-BI. RT-qPCR measurement of (A) Il1b mRNA and (B) Ccl5 mRNA following incubation with discoidal Por-NPs and stimulation with LPS (10 ng/mL) (n = 3 biological replicates). iBMDMs were pre-incubated with PBS, methyl-β-cyclodextrin (MβCD, 4 % v/v), discoidal or CO-loaded Por-NPs (10 μg/mL) then stimulated with LPS (10 ng/mL) before RT-qPCR quantification of the mRNA levels of (C) Il1b and (D) Ccl5 . The nuclear fractions of (E) unstimulated and (F) LPS-stimulated iBMDMs were isolated and nuclear p65-NFκB protein levels (∼65 kDa) were assessed by Western blotting (n = 5–6 biological replicates). TATA binding protein (TBP, 37 kDa) was used as the nuclear protein loading control. Data expressed as Mean ± SD. ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001, ∗∗∗∗ P < 0.0001 by one-way ANOVA with post-hoc Tukey's multiple comparisons.

    Journal: Materials Today Bio

    Article Title: Theranostic porphyrin nanoparticles identify atherosclerosis via multimodal imaging and elicit atheroprotective effects

    doi: 10.1016/j.mtbio.2025.102202

    Figure Lengend Snippet: Role of SR-B I and cholesterol efflux in the anti-inflammatory properties of Por-NPs in macrophages . iBMDMs were transfected with SR-BI siRNA (100 nM) to knockdown SR-BI. RT-qPCR measurement of (A) Il1b mRNA and (B) Ccl5 mRNA following incubation with discoidal Por-NPs and stimulation with LPS (10 ng/mL) (n = 3 biological replicates). iBMDMs were pre-incubated with PBS, methyl-β-cyclodextrin (MβCD, 4 % v/v), discoidal or CO-loaded Por-NPs (10 μg/mL) then stimulated with LPS (10 ng/mL) before RT-qPCR quantification of the mRNA levels of (C) Il1b and (D) Ccl5 . The nuclear fractions of (E) unstimulated and (F) LPS-stimulated iBMDMs were isolated and nuclear p65-NFκB protein levels (∼65 kDa) were assessed by Western blotting (n = 5–6 biological replicates). TATA binding protein (TBP, 37 kDa) was used as the nuclear protein loading control. Data expressed as Mean ± SD. ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001, ∗∗∗∗ P < 0.0001 by one-way ANOVA with post-hoc Tukey's multiple comparisons.

    Article Snippet: iBMDMs were incubated with transfection reagent alone (Lipofectamine® RNAiMAX, 13778150, Thermofisher), scrambled control siRNA (sc-37007, Santa Cruz) or SR-BI siRNA (sc-44753, Santa Cruz) in optiMEM at 100 nM of siRNA for 6 h at 37 o C. Media was replaced and cells incubated for a total of 48 h iBMDMs were incubated with PBS or discoidal Por-NPs (10 μg/mL, R4F concentration, 24 h) then stimulated with LPS for 16 h for inflammatory gene assessments.

    Techniques: Transfection, Knockdown, Quantitative RT-PCR, Incubation, Isolation, Western Blot, Binding Assay, Control

    Overexpression of SR-BI in ccRCC. Relative mRNA expression of SR-BI in normal kidney and ccRCC tissues ( a ), normal kidney cell line and ccRCC cell lines ( b ) by qRT-PCR. Protein expression of SR-BI in normal kidney and ccRCC tissues ( c ), normal kidney cell line and ccRCC cell lines ( d ) by western blot. Representative images of ORO staining, HE staining and IHC analysis of SR-BI protein in normal kidney and ccRCC tissues ( e ) (original magnification ×400). * P < 0.05, ** P < 0.01

    Journal: BMC Cancer

    Article Title: Up-regulation of SR-BI promotes progression and serves as a prognostic biomarker in clear cell renal cell carcinoma

    doi: 10.1186/s12885-017-3761-z

    Figure Lengend Snippet: Overexpression of SR-BI in ccRCC. Relative mRNA expression of SR-BI in normal kidney and ccRCC tissues ( a ), normal kidney cell line and ccRCC cell lines ( b ) by qRT-PCR. Protein expression of SR-BI in normal kidney and ccRCC tissues ( c ), normal kidney cell line and ccRCC cell lines ( d ) by western blot. Representative images of ORO staining, HE staining and IHC analysis of SR-BI protein in normal kidney and ccRCC tissues ( e ) (original magnification ×400). * P < 0.05, ** P < 0.01

    Article Snippet: Small interfering RNA (siRNA) targeting SR-BI mRNA (si-SR-BI) and scrambled negative control (si-NC) was designed and synthesized by Genepharma (Shanghai, China).

    Techniques: Over Expression, Expressing, Quantitative RT-PCR, Western Blot, Staining

    Correlation between SR-BI mRNA expression and clinicopathological parameters of ccRCC patients

    Journal: BMC Cancer

    Article Title: Up-regulation of SR-BI promotes progression and serves as a prognostic biomarker in clear cell renal cell carcinoma

    doi: 10.1186/s12885-017-3761-z

    Figure Lengend Snippet: Correlation between SR-BI mRNA expression and clinicopathological parameters of ccRCC patients

    Article Snippet: Small interfering RNA (siRNA) targeting SR-BI mRNA (si-SR-BI) and scrambled negative control (si-NC) was designed and synthesized by Genepharma (Shanghai, China).

    Techniques: Expressing

    Knockdown of SR-BI inhibited the growth of ccRCC cells. Expression of SR-BI mRNA ( a ) and protein ( b ) was effectively inhibited by specific siRNA in ccRCC cell lines. MTT assays showed that proliferative ability of ccRCC cells transfected with si-SR-BI significantly decreased compared with control cells ( c ). Plate colony formation assays exhibited that ccRCC cells transfected with si-SR-BI formed fewer colonies than control cells ( d-e ). * P < 0.05, ** P < 0.01

    Journal: BMC Cancer

    Article Title: Up-regulation of SR-BI promotes progression and serves as a prognostic biomarker in clear cell renal cell carcinoma

    doi: 10.1186/s12885-017-3761-z

    Figure Lengend Snippet: Knockdown of SR-BI inhibited the growth of ccRCC cells. Expression of SR-BI mRNA ( a ) and protein ( b ) was effectively inhibited by specific siRNA in ccRCC cell lines. MTT assays showed that proliferative ability of ccRCC cells transfected with si-SR-BI significantly decreased compared with control cells ( c ). Plate colony formation assays exhibited that ccRCC cells transfected with si-SR-BI formed fewer colonies than control cells ( d-e ). * P < 0.05, ** P < 0.01

    Article Snippet: Small interfering RNA (siRNA) targeting SR-BI mRNA (si-SR-BI) and scrambled negative control (si-NC) was designed and synthesized by Genepharma (Shanghai, China).

    Techniques: Knockdown, Expressing, Transfection, Control